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Ajouter le résultat dans votre panier Affiner la rechercheAssessing the impact of protonating acid combinations in e‑cigarette liquids / Justin Frosina (2023)
Titre : Assessing the impact of protonating acid combinations in e‑cigarette liquids : a randomised, crossover study on nicotine pharmacokinetics Type de document : document électronique Auteurs : Justin Frosina, Auteur ; Michael McEwan, Auteur ; James Ebajemito, Auteur ; Jesse Thissen, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Scientific Reports Importance : 11 p. Présentation : graph,tab. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac:constituant:alcaloïde:nicotine
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] étudeMots-clés : Pharmacocinétique - e-liquide Index. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : The addition of protonating acids to e-cigarette liquid formulations (e-liquids) enhances nicotine bioavailability in e-cigarette use. However, little is known about the impact of different combinations of protonating acid on nicotine pharmacokinetics. The objectives of this study were to compare pharmacokinetics of nicotine absorption following use of a closed-system e-cigarette, containing e-liquids with two different nicotine levels and with different ratios of three common protonating acids—lactic, benzoic and levulinic. In a randomised, controlled, crossover study, nicotine pharmacokinetics and product liking were assessed for prototype e-liquids used in a Vuse e-cigarette containing either 3.5% or 5% nicotine and varying ratios of lactic, benzoic and/or levulinic acid. During an 8-day confinement period, 32 healthy adult current cigarette smokers/e-cigarette dual users used a single study e-liquid each day during 10-min fixed and ad libitum use periods after overnight nicotine abstinence. For most comparisons, Cmax and AUC 0–60 following both fixed and ad libitum puffing were significantly higher for e-liquids containing 5% nicotine compared with 3.5% nicotine. However, Cmax and AUC 0–60 were not statistically different for 5% nicotine e-liquids containing varying ratios of lactic, levulinic and benzoic acid when compared to an e-liquid containing lactic acid only. Mean scores for product liking were similar for all e-liquid formulations assessed, regardless of nicotine concentration, acid content, and whether the product was used in a fixed or ad libitum puffing regimen. While e-liquid nicotine concentration significantly affected users’ nicotine uptake, the different combinations of benzoic, levulinic and lactic acid in the e-liquids assessed had limited impact on nicotine pharmacokinetics and product liking scores. En ligne : https://doi.org/10.1186/s43162-024-00274-z Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10257 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Carcinogenic and non‑carcinogenic health risk assessment of organic compounds and heavy metals in electronic cigarettes Type de document : document électronique Auteurs : Siyuan Zhao, Auteur ; Xi Zhang, Auteur ; Junji Wang, Auteur ; Jianzai Lin, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Scientific Reports Importance : 13 p. Présentation : tab. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac:fumée:acétone
[TABAC] chimie du tabac:fumée:acroléine
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] étude
[TABAC] tabagisme:risqueIndex. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : E-cigarettes are now very popular in the world. Compared to traditional cigarettes, e-cigarettes are often considered safer and healthier. However, their safety remains controversial and requires further research and regulation. In this study, we aimed to understand the possible hazards to humans of four compounds (formaldehyde, acetaldehyde, acrolein, and acetone) and seven heavy metals (arsenic, cadmium, manganese, lead, copper, nickel, and chromium) contained in e-cigarette liquids and aerosols and perform a health risk assessment. We searched PubMed, CNKI, and other databases for relevant literature to obtain data on organic compounds and heavy metals in e-cigarette liquids and aerosols, and conducted acute, chronic, and carcinogenic risk assessments of various chemicals by different exposure routes. This study showed that exposure to four organic compounds and seven heavy metals in e-cigarette aerosols and e-liquids can cause varying levels of health risks in humans through different routes, with the inhalation route posing a higher overall risk than dermal exposure and oral intake. Various chemicals at high exposure doses can produce health risks beyond the acceptable range. E-cigarette designers must improve their products by changing the composition of the e-liquid and controlling the power of the device to reduce the health effects on humans. En ligne : https://doi.org/10.1038/s41598-023-43112-y Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10256 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Emissions from conventional and electronic waterpipes relative to cigarettes and a heated tobacco product Type de document : document électronique Auteurs : Peter J. Wilkinson, Auteur ; A Clarke, Auteur ; Ian M. Fearon, Auteur ; Ronan Barry, Auteur Editeur : Springer Nature Année de publication : 2024 Collection : Scientific Reports Importance : p. 1-16 Présentation : graph.; tab. Langues : Anglais (eng) Catégories : [TABAC] chimie du tabac:substance toxique
[TABAC] chimie du tabac:tabac fumé:chicha
[TABAC] étude
[TABAC] tabagisme:risqueIndex. décimale : TA 1.1.4 Chicha – Narguilé Résumé : Harms associated with tobacco product use, including waterpipe, are due to inhalational exposure to toxicants either present in tobacco or formed during the process of combustion. We assessed levels of 37 toxicants in aerosol emissions from conventional waterpipe heated with different charcoals and also with a heat management device (HMD), from the IQOS heated tobacco product (HTP), and the ‘OOKA’ electronic waterpipe. We also utilised literature data on toxicant yields in 3R4F reference cigarette smoke. When taking use patterns into account, toxicant yields were substantially lower in conventional waterpipe aerosol compared with cigarette smoke. Toxicant yields in electronic waterpipe aerosol were substantially lower than those in conventional waterpipe aerosol, both on a per session basis and when taking typical use patterns into account. Numerous toxicants in conventional waterpipe aerosol were absent in electronic waterpipe aerosol. In summary, during typical use conventional waterpipe emits fewer, and lower levels of, a number of toxicants relative to combustible cigarette smoke. In addition, electronically heating shisha further reduces toxicant levels, and many toxicants are absent in OOKA electronic waterpipe aerosol. These findings have important implications concerning toxicant exposure among waterpipe users, and for understanding how to potentially reduce health risks associated with waterpipe use. En ligne : https://doi.org/10.21203/rs.3.rs-4637991/v1 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10498 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Forecasting vaping health risks through neural network model prediction of flavour pyrolysis reactions Type de document : document électronique Auteurs : Akihiro Kishimoto, Auteur ; Dan Wu, Auteur ; Donal F. O’Shea, Auteur Editeur : Springer Nature Année de publication : 2024 Collection : Scientific Reports num. 14 Importance : 14 p. Présentation : graph., tab., ill. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac
[TABAC] chimie du tabac:constituant:additif:agent de saveur
[TABAC] tabagisme:effet du tabac:effet neurologiqueMots-clés : e-liquide Index. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : Vaping involves the heating of chemical solutions (e-liquids) to high temperatures prior to lung inhalation. A risk exists that these chemicals undergo thermal decomposition to new chemical
entities, the composition and health implications of which are largely unknown. To address this concern, a graph-convolutional neural network (NN) model was used to predict pyrolysis reactivity
of 180 e-liquid chemical flavours. The output of this supervised machine learning approach was a dataset of probability ranked pyrolysis transformations and their associated 7307 products. To refine this dataset, the molecular weight of each NN predicted product was automatically correlated with experimental mass spectrometry (MS) fragmentation data for each flavour chemical. This blending of deep learning methods with experimental MS data identified 1169 molecular weight matches that prioritized these compounds for further analysis. The average number of discrete matches per flavour between NN predictions and MS fragmentation was 6.4 with 92.8% of flavours having at least one match. Globally harmonized system classifications for NN/MS matches were extracted
from PubChem, revealing that 127 acute toxic, 153 health hazard and 225 irritant classifications were predicted. This approach may reveal the longer-term health risks of vaping in advance of clinical diseases emerging in the general population.En ligne : https://doi.org/10.1038/s41598-024-59619-x Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10289 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Physical and chemical characterizations of a reference e‑cigarette used in animal testing Type de document : document électronique Auteurs : Sébastien Soulet, Auteur ; Léa Constant, Auteur ; Vanille Quinty, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Scientific Reports Importance : 10 p. Présentation : graph. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] étudeMots-clés : Expérimentation animale :-(
caractéristiques physiques... du produitIndex. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : A minimal necessary condition for preclinical studies to contribute to risk assessments of e-cigarettes (ECs) is the ability to expose laboratory animals to an appropriate dosage of aerosols. In this study, we examined the fulfilment of this essential consistency condition for the ECX-Joyetech E-Vic Mini (ECX),a piece of computerized exposure equipment manufactured by SCIREQ, which has been employed by numerous in vivo testing. We began by calibrating the customary Evic VTC mini device mod and the 4 coils available, reproducing in the laboratory the operation of the ECX in the power-control and temperature-control modes, using puffing parameters recommended by its documentation. We then conducted the following tests for each coil: (1) verifying whether the generated aerosols satisfy an optimal operational regime, free from overheating, as determined by a linear relation between the mass of vaporized e-liquid vs. supplied power and (2) obtaining the mean yields of aldehydes for each of the tested power settings and coils. The results of these tests show that, under the main conditions used in in vivo testing, the ECX equipment fails to comply with these consistency requirements, especially for coils with low subohm resistance, a shortcoming that can be corrected by applying much larger airflows for these coils. Therefore, the outcomes of preclinical studies using the ECX equipment should be examined with great scepticism and subjected to further testing. En ligne : https://doi.org/10.1038/s41598-023-43733-3 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10255 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : The associations of parental smoking, quitting and habitus with teenager e‑cigarette, smoking, alcohol and other drug use in GUI Cohort ’98 Type de document : document électronique Auteurs : Salome Sunday, Auteur ; Luke Clancy, Auteur ; Joan Hanafin, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Scientific Reports num. 13(20105) Importance : 11 p. Présentation : graph.; tab. Langues : Anglais (eng) Catégories : [DIVERS] personne:famille:adolescent
[DIVERS] personne:famille:enfant
[DIVERS] personne:par âge:jeune
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] tabagisme:aspect psychologique:comportement
[TABAC] tabagisme:risque:facteur associé:alcool
[TABAC] tabagisme:risque:facteur associé:drogue
[TABAC] tabagisme:tabagisme actif:tabagisme parentalIndex. décimale : TA 2.4.1 Enfants et jeunes Résumé : We analyse parental smoking and cessation (quitting) associations with teenager e-cigarette, alcohol, tobacco smoking and other drug use, and explore parental smoking as a mechanism for social reproduction. We use data from Waves 1–3 of Growing Up in Ireland (Cohort ’98). Our analytic sample consisted of n = 6,039 participants reporting in all 3 Waves. Data were collected in Waves 1 and 2 when the children were 9 and 13 years old and in Wave 3 at age 17/18 years. Generalized Estimating Equations (GEE) models were used to analyse teenage substance use at Wave 3. Parental smoking was associated with significantly increased risk of all teenage substance use, adjusted odds ratios were aOR2.13 (ever e-cigarette use); aOR1.92 (ever alcohol use); aOR1.88 (current alcohol use); aOR1.90 (ever use of other drugs); aOR2.10 (ever-smoking); and aOR1.91 (current smoking). Primary caregiver smoking cessation (quitting) was associated with a lower risk for teenager current smoking aOR0.62, ever e-cigarette use aOR 0.65 and other drug use aOR 0.57. Primary caregiver smoking behaviour had greater associations than secondary, and age13 exposure more than age 9. Habitus seems to play a role and wealth was protective for teenage smoking. The findings suggest that prevention interventions should target both caregivers and their children. En ligne : https://doi.org/10.1038/s41598-023-47061-4 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10606 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : The combination of propylene glycol and vegetable glycerin e‑cigarette aerosols induces airway inflammation and mucus hyperconcentration Type de document : document électronique Auteurs : Michael D. Kim, Auteur ; Samuel Chung, Auteur ; Nathalie Baumlin, Auteur ; Jian Qian, Auteur ; Robert N. Montgomery, Auteur Editeur : Springer Nature Année de publication : 2024 Collection : Scientific Reports num. 14 - 1942 Importance : 14 p. Présentation : graph., ill. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] tabagisme:pathologie:pathologie respiratoire
[TABAC] tabagisme:risqueMots-clés : e-liquide Index. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : Despite concerns over their safety, e-cigarettes (e-cigs) remain a popular tobacco product. Although nicotine and flavors found in e-cig liquids (e-liquids) can cause harm in the airways, whether the delivery vehicles propylene glycol (PG) and vegetable glycerin (VG) are innocuous when inhaled remains unclear. Here, we investigated the effects of e-cig aerosols generated from e-liquid containing only PG/VG on airway inflammation and mucociliary function in primary human bronchial epithelial cells (HBEC) and sheep. Primary HBEC were cultured at the air–liquid interface (ALI) and exposed to e-cig aerosols of 50%/50% v/v PG/VG. Ion channel conductance, ciliary beat frequency, and the expression of inflammatory markers, cell type-specific markers, and the major mucins MUC5AC and MUC5B were evaluated after seven days of exposure. Sheep were exposed to e-cig aerosols of PG/VG for five days and mucus concentration and matrix metalloproteinase-9 (MMP-9) activity were measured from airway secretions. Seven-day exposure of HBEC to e-cig aerosols of PG/VG caused a significant reduction in the activities of apical ion channels important for mucus hydration, including the cystic fibrosis transmembrane conductance regulator (CFTR) and large conductance, Ca2+- activated, and voltage-dependent K+ (BK) channels. PG/VG aerosols significantly increased the mRNA expression of the inflammatory markers interleukin-6 (IL6), IL8, and MMP9, as well as MUC5AC.The increase in MUC5AC mRNA expression correlated with increased immunostaining of MUC5AC protein in PG/VG-exposed HBEC. On the other hand, PG/VG aerosols reduced MUC5B expression leading overall to higher MUC5AC/MUC5B ratios in exposed HBEC. Other cell type-specific markers, including forkhead box protein J1 (FOXJ1), keratin 5 (KRT5), and secretoglobin family 1A member 1 (SCGB1A1) mRNAs, as well as overall ciliation, were significantly reduced by PG/VG exposure. Finally,
PG/VG aerosols increased MMP-9 activity and caused mucus hyperconcentration in sheep in vivo. E-cig aerosols of PG/VG induce airway inflammation, increase MUC5AC expression, and cause dysfunction
of ion channels important for mucus hydration in HBEC in vitro. Furthermore, PG/VG aerosols increase MMP-9 activity and mucus concentration in sheep in vivo. Collectively, these data show that e-cig aerosols containing PG/VG are likely to be harmful in the airways.
En ligne : https://doi.org/10.1038/s41598-024-52317-8 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10227 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
