Active smoking compromises IVF outcome and affects ovarian reserve / Thomas Freour (2008)  

Public Titre : Active smoking compromises IVF outcome and affects ovarian reserve Type de document : document électronique Auteurs : Thomas Freour, Auteur ; Damien Masson, Auteur ; Sophie Mirallie, Auteur ; Kalyane Bach, Auteur ; Miguel Jean, Auteur ; Thomas Dejoie, Auteur ; Paul Barriere, Auteur Editeur : Elsevier Science Direct Année de publication : 2008 Collection : Reproductive BioMedicine Online, ISSN 1472-6491 num. vol.16 n°1 Importance : p.96-102 Langues : Français (fre) Catégories : [TABAC] tabagisme:effet du tabac:altération de la fonction sexuelle:effet sur la fertilité [TABAC] tabagisme:risque:facteur associé:grossesse Index. décimale : TA 3.2.2.7 Grossesse et fœtus Résumé : Although the association between smoking and female infertility is now largely demonstrated, the proportion of smokers in women of reproductive age remains important. Tobacco contains numerous toxicants that could affect ovarian reserve and lead to poor prognosis in assisted reproductive techniques. To investigate the effect of female active smoking on ovarian reserve and IVF outcome, smoking status, hormonal status, i.e. serum FSH, oestradiol and anti-Müllerian hormone (AMH), ovarian response to hyperstimulation, i.e. mature oocytes retrieved, and IVF outcome, i.e. clinical pregnancy, were retrospectively analysed in 111 women undergoing IVF-embryo transfer cycles. Compared with non-smokers (n = 71), active smoking women (n = 40) had decreased ovarian response (12.12 ± 5 versus 8.62 ± 4 mature oocytes retrieved) to hyperstimulation and lower clinical pregnancy rate (29.6 versus 10.0%). Serum AMH concentrations were lower in the smoker group (3.86 ± 1.92 versus 3.06 ± 1.68 μg/l) and had no predictive value for ovarian response, inversely to non-smokers. In conclusion, active smoking is associated with poor prognosis in assisted reproduction cycles, i.e. ovarian response and pregnancy, and leads to altered ovarian reserve, as reflected by decreased serum AMH concentrations. En ligne : https://doi.org/10.1016/S1472-6483(10)60561-5 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10104

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High-quality embryos maintain high pregnancy rates in passive smokers but not in active smokers / Avi Ben-Haroush (2011)  

Public Titre : High-quality embryos maintain high pregnancy rates in passive smokers but not in active smokers Type de document : document électronique Auteurs : Avi Ben-Haroush, Auteur ; Jacob Ashkenazi, Auteur ; Onit Sapir, Auteur ; Haim Pinkas, Auteur ; Benjamin Fisch, Auteur ; Jacob Farhi, Auteur Editeur : Elsevier Science Direct Année de publication : 2011 Collection : Reproductive BioMedicine Online, ISSN 1472-6491 num. 22(1) Importance : p.44-49 Langues : Anglais (eng) Catégories : [TABAC] étude [TABAC] tabagisme:effet du tabac:altération de la fonction sexuelle:effet sur la fertilité [TABAC] tabagisme:risque:facteur associé:grossesse [TABAC] tabagisme:tabagisme actif [TABAC] tabagisme:tabagisme passif Index. décimale : TA 3.2.2.7 Grossesse et fœtus Résumé : This study assesses the effect of passive and active smoking on pregnancy rates after IVF with transfer of high-quality embryos. In a cohort study, women attending the IVF unit in 2006–2007 with favourable parameters for pregnancy (<38 years; less than three IVF cycles, transfer of two highest-grade embryos) grouped by smoking status were included. The cohort included 237 patients/cycles: 42 smokers, 195 non-smokers. The clinical pregnancy rate was significantly lower in smokers (35.7% versus 55.4%,P = 0.021, OR = 0.44 (95% CI 0.22–0.89)), even after conditional stratification on covariates (passive smoker, passive or partner smoker, age group). The live-birth rate was lower in smokers (28.6% versus 42.6%), but the difference was not statistically significant(OR = 0.54 (0.26–1.11)). Among non-smokers, there was no difference in pregnancy rate by passive or partner smoking. On logistic regression, variables predicting pregnancy were age <35 years (P = 0.008, OR = 2.58 (1.2–5.2)) and non-smoking (P = 0.003,OR = 3.47 (1.51–7.98)). In conclusion, transfer of high-quality embryos does not overcome the negative effect of active smoking on pregnancy rate in IVF treatment. The endometrium is apparently involved in the mechanism underlying IVF failure in smokers. En ligne : https://doi.org/10.1016/j.rbmo.2010.09.012 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10101

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