Chronic exposure to e-cig aerosols during early development causes vascular dysfunction and offspring growth deficits / Marcus, R. Orzabal (2019)  

Public Titre : Chronic exposure to e-cig aerosols during early development causes vascular dysfunction and offspring growth deficits Type de document : document électronique Auteurs : Marcus, R. Orzabal, Auteur ; Emilie, R. Lundr-Young, Auteur ; Josue, I. Ramirez, Auteur Editeur : Elsevier Année de publication : 2019 Collection : Translational Research num. 207 Importance : p. 70-82 Présentation : ill, tab., graph Langues : Anglais (eng) Catégories : [TABAC] chimie du tabac:constituant:alcaloïde:nicotine [TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique [TABAC] tabagisme:risque:facteur associé:grossesse:foetus [TABAC] tabagisme:tabagisme actif:tabagisme féminin:tabagisme durant la grossesse Index. décimale : TA 3.2.2.7 Grossesse et fœtus Résumé : Increasing popularity of electronic cigarettes (e-cigs), including among women of reproductive age, is attributed to its perceived safety compared to conventional tobacco. However, there is a major knowledge gap surrounding the effects of e-cig aerosols on pregnancy and fetal development. We aimed to evaluate the effects of vaping e-cigs during gestation on offspring growth and to asses if growth deficits are accompanied by altered maternal and fetal vascular hemodynamics. Sprague ?Dawley dams were assigned to Pair-Fed Control, Pair-Fed Juice, or Juice+Nicotine groups, and then underwent either a prenatal or prenatal+postnatal exposure paradigm in a custom-engineered vaping system. Mass spectrometry identified major aerosolized constituents from e-cig vaping. The Juice+Nicotine group exhibited significantly decreased fetal weight and crown-rump length (#46.56%, and #23.83%, respectively). Pre- and postnatal exposure to Juice+Nicotine resulted in decreased pup weight at postnatal day (PND) 4?10. Crown-rump length was decreased by 24.71% on PND 10. Blood flow in the Juice+Nicotine group was decreased in the maternal uterine and fetal umbilical circuits by 49.50% and 65.33%, respectively. We conclude that chronic exposure to e-cig aerosols containing nicotine during early development can have deleterious health effects on the exposed offspring. Vaping e-cigs containing nicotine during pregnancy lead to a reduction in offspring weight and crown-rump length, associated with a marked decrease in blood flow in both the maternal uterine and fetal umbilical circulation (a strong indicator of growth restriction). Thus, chronic exposure to e-cig aerosols containing nicotine can lead to potentially harmful developmental effects in early life En ligne : https://doi.org/10.1016/j.trsl.2019.01.001 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9759

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