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The neurobiological basis for partail agonist treatment of nicotine dependance / J. Foulds (2006)
Titre : The neurobiological basis for partail agonist treatment of nicotine dependance : varenicline Type de document : texte imprimé Auteurs : J. Foulds, Auteur Editeur : John Wiley & Sons Année de publication : 2006 Collection : International journal of clinical practice, ISSN 1368-5031 num. Vol 60, n. 5 Importance : p.571-576 Présentation : ill., tab. Langues : Anglais (eng) Catégories : [TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:varénicline Index. décimale : TA 6.2.3.1.4 Autres substituts nicotiniques Résumé : Abstract
Smoking cessation has major health benefits for men and women of all ages. However, most smokers are addicted to nicotine and fail repeatedly in their attempts to quit. Stimulation of nicotinic receptors in the brain, particularly alpha4beta2 receptors, releases dopamine in the meso-limbic area of the brain and is reinforcing. Nicotine abstinence reduces dopamine release, and this is associated with withdrawal symptoms and craving for nicotine. Eight current pharmacotherapies--bupropion, nortriptyline, clonidine and nicotine patch, gum, inhaler, lozenge and nasal spray--are moderately effective aids to smoking cessation. Each is significantly better than placebo, but approximately 80% of patients using one of these medications return to smoking within the first year. Varenicline, a specific alpha4beta2 nicotinic receptor partial agonist, is a new pharmacotherapy that stimulates dopamine and simultaneously blocks nicotine receptors. Phase II and III trials have yielded promising results suggesting that varenicline could be an important advance in the treatment of nicotine dependence.
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Code-barres Cote Support Localisation Section Disponibilité TA 005480 TA 6.2.3.1.4 FOU N Article/Périodique Bibliothèque FARES Tabac Consultation sur place
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