Does in utero exposure to heavy maternal smoking induce nicotine withdrawal symptoms in neonates? / Véronique Godding (2004)  

Public Titre : Does in utero exposure to heavy maternal smoking induce nicotine withdrawal symptoms in neonates? Type de document : document électronique Auteurs : Véronique Godding, Auteur ; Chrisitine Bonnier, Auteur ; Leon Fiasse, Auteur ; Marianne Michel, Auteur ; Étienne Longueville, Auteur ; Patrick Lebecque, Auteur ; Annie Robert, Auteur ; Laurence Galanti, Auteur Editeur : Springer Année de publication : 2004 Collection : Pediatric Research, ISSN 1530-0447 num. 55 Importance : p.645–651 Langues : Anglais (eng) Catégories : [DIVERS] personne:famille:nourrisson [DIVERS] personne:par sexe:femme:femme enceinte [TABAC] chimie du tabac:constituant:alcaloïde:nicotine [TABAC] étude [TABAC] tabagisme:aspect psychologique:comportement:addiction [TABAC] tabagisme:risque:facteur associé:grossesse:foetus [TABAC] tabagisme:tabagisme actif:tabagisme parental [TABAC] tabagisme:tabagisme passif Index. décimale : TA 3.2.2.7 Grossesse et fœtus Résumé : Maternal drug use during pregnancy is associated with fetal passive addiction and neonatal withdrawal syndrome. Cigarette smoking—highly prevalent during pregnancy—is associated with addiction and withdrawal syndrome in adults. We conducted a prospective, two-group parallel study on 17 consecutive newborns of heavy-smoking mothers and 16 newborns of nonsmoking, unexposed mothers (controls). Neurologic examinations were repeated at days 1, 2, and 5. Finnegan withdrawal score was assessed every 3 h during their first 4 d. Newborns of smoking mothers had significant levels of cotinine in the cord blood (85.8 ± 3.4 ng/mL), whereas none of the controls had detectable levels. Similar findings were observed with urinary cotinine concentrations in the newborns (483.1 ± 2.5 μg/g creatinine versus 43.6 ± 1.5 μg/g creatinine; p = 0.0001). Neurologic scores were significantly lower in newborns of smokers than in control infants at days 1 (22.3 ± 2.3 versus 26.5 ± 1.1; p = 0.0001), 2 (22.4 ± 3.3 versus 26.3 ± 1.6; p = 0.0002), and 5 (24.3 ± 2.1 versus 26.5 ± 1.5; p = 0.002). Neurologic scores improved significantly from day 1 to 5 in newborns of smokers (p = 0.05), reaching values closer to control infants. Withdrawal scores were higher in newborns of smokers than in control infants at days 1 (4.5 ± 1.1 versus 3.2 ± 1.4; p = 0.05), 2 (4.7 ± 1.7 versus 3.1 ± 1.1; p = 0.002), and 4 (4.7 ± 2.1 versus 2.9 ± 1.4; p = 0.007). Significant correlations were observed between markers of nicotine exposure and neurologic-and withdrawal scores. We conclude that withdrawal symptoms occur in newborns exposed to heavy maternal smoking during pregnancy. En ligne : https://doi.org/10.1203/01.PDR.0000112099.88740.4E Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10112

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