Electronic cigarette use behaviors in people with HIV who smoke tobacco cigarettes / Jonathan Shuter (2023)  

Public Titre : Electronic cigarette use behaviors in people with HIV who smoke tobacco cigarettes Type de document : document électronique Auteurs : Jonathan Shuter, Auteur ; Ryung S. Kim, Auteur ; Krystal L. Cleven, Auteur ; Cassandra A. Stanton, Auteur Editeur : Research Square Année de publication : 2023 Importance : 18 p. Présentation : tab. Langues : Français (fre) Catégories : [DIVERS] géographie:Amérique:Amérique du Nord:Etats-Unis [TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique [TABAC] étude [TABAC] tabagisme:pathologie:pathologie infectieuse:sida [TABAC] tabagisme:tabagisme actif:fumeur [TABAC] tabagisme:tabagisme passif:non-fumeur Index. décimale : TA 4.1 Habitudes tabagiques Résumé : Objectives. To describe electronic cigarette (e-cigarette) usage behaviors, beliefs, and spirometry patterns in people with HIV (PWH) who smoke tobacco cigarettes. Design: Cross-sectional, observational, pilot study conducted in an HIV care center in the Bronx, New York. Methods Enrolled PWH who confirmed tobacco cigarette usage completed an audio computer-assisted self-interview and spirometry. Because a minority of PWH tobacco users have ever used e-cigarettes, we purposely oversampled current and past e-cigarette users. Results We enrolled 42 participants into the study. Of these, 19 were current e-cigarette users, 13 were past users, and 10 were never users. Current and past e-cigarette users were significantly younger than never users, and they were more likely to have ever used other tobacco products (mostly pipes and cigars). There were no significant differences in tobacco smoking frequency, daily cigarette consumption, nicotine dependence, or motivation to quit between e-cigarette users and non-users. Current and past users were less likely to demonstrate an obstructive pattern on spirometry than never users. Current e-cigarette users cited assistance in attempting to quit tobacco cigarettes as the most common reason for their use. Our sample used eight different vaping devices and most commonly used tobacco/nicotine as their vaping substrate. Conclusions PWH tobacco cigarette smokers who use e-cigarettes most commonly vape tobacco/nicotine products. Current e-cigarette users did not smoke fewer tobacco cigarettes per day than non-users. The observation that those who had never used e-cigarettes were more likely to demonstrate obstruction on spirometry was surprising and may merit further investigation. En ligne : https://doi.org/10.21203/rs.3.rs-3359595/v1 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10601

Aucun avis, veuillez vous identifier pour ajouter le vôtre !

Single-cell RNA sequencing reveals heterogeneity of ALI model and epithelial cell alterations after exposure to electronic cigarette vapor / Meng-yun Cai (2023)  

Public Titre : Single-cell RNA sequencing reveals heterogeneity of ALI model and epithelial cell alterations after exposure to electronic cigarette vapor Type de document : document électronique Auteurs : Meng-yun Cai, Auteur ; Xiaofan Mao, Auteur ; Beiying Zhang, Auteur Editeur : Research Square Année de publication : 2023 Importance : 23 p. Présentation : graph.; ill. Langues : Anglais (eng) Catégories : [TABAC] chimie du tabac:constituant:additif:agent de saveur [TABAC] chimie du tabac:constituant:alcaloïde:nicotine [TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique [TABAC] étude [TABAC] tabagisme:risque [TABAC] tabagisme:tabagisme actif Index. décimale : TA 3.2.2.4 Pathologies respiratoires (sauf 3.2.2.1, 3.2.2.2, 3.2.2.3) Résumé : Background Electronic cigarettes (e-cigarettes) have been advertised as a healthier alternative to traditional cigarettes; however, their exact effects on the bronchial epithelium are poorly understood. Air-liquid interface (ALI) culture allows human primary bronchial epithelial cells to differentiate into bronchial epithelium (ALI-HBE), providing an in vitro model that simulates the biological characteristics of normal bronchial epithelium. Methods Single-cell RNA sequencing of ALI-HBE was used to reveal previously unrecognized transcriptional heterogeneity within the human bronchial epithelium and cell type–specific responses to acute exposure to e-cigarette vapor (e-vapor) containing distinct components (nicotine and/or flavoring). Results Acute exposure to e-vapor containing nicotine affected gene expression related to secretory function and basal-to-secretory transformation. In addition, acute exposure to e-vapor containing flavoring might promote susceptibility to virus infection and activate epithelial-to-mesenchymal transition. Conclusion The ALI-HBE model recapitulates the heterogeneity and transcriptional characteristics of human bronchial epithelium. Single-cell sequencing data provided high-resolution insights into e-vapor–induced remodeling of bronchial epithelium. The data also indicate factors on bronchial epithelial cells that may promote SARS-CoV-2 infection and suggest therapeutic targets for restoring normal bronchial epithelium function after e-cigarette use. En ligne : https://doi.org/10.21203/rs.3.rs-3708689/v1 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10580

Aucun avis, veuillez vous identifier pour ajouter le vôtre !