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National Institute of Environmental Health Sciences
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Ajouter le résultat dans votre panier Affiner la rechercheCombined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice / David Drummond (2017)
Titre : Combined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice Type de document : document électronique Auteurs : David Drummond, Auteur ; Mélissa Baravalle - Einaudi, Auteur ; Guillaume Lezmi, Auteur Editeur : National Institute of Environmental Health Sciences Année de publication : 2017 Collection : Environmental health perspectives, ISSN 0091-6765 Importance : 31 p. Présentation : tab., ill. Langues : Français (fre) Catégories : [DIVERS] personne:par âge:jeune
[TABAC] chimie du tabac:fumée
[TABAC] étude
[TABAC] tabagisme:pathologie:pathologie respiratoire
[TABAC] tabagisme:risque:facteur associé:grossesse:foetusMots-clés : expérimentation animale Index. décimale : TA 3.2.2.4 Pathologies respiratoires (sauf 3.2.2.1, 3.2.2.2, 3.2.2.3) Résumé : Fetal determinants of airway function, such as in utero exposure to maternal cigarette smoke (CS), may create a predisposition to adult airflow obstruction and chronic obstructive pulmonary disease (COPD) in adulthood. It has been suggested that active smoking in adolescence and preexisting airflow obstruction have synergistic deleterious effects.
Objective:
We used a mouse model to investigate whether there is a synergistic effect of exposure to CS in utero and during adolescence on lung function.
Methods:
Female C57Bl/6J mice were exposed to CS or to filtered room air during pregnancy. Exposure to CS began 2 weeks before mating and continued until delivery. After birth, the pups were not exposed to CS until day 21 (D21). Between D21 and D49, corresponding to “adolescence,” litters were randomized for an additional 4 weeks of exposure to CS. Lung morphometry, lung mechanics, and the expression of genes involved in senescence were evaluated in different subsets of mice on D21 and D49.
Results:
In utero exposure to CS induced significant lung function impairment by D21. CS exposure between D21 and D49 induced significant functional impairment only in mice exposed to CS prenatally. On D49, no difference was observed between subgroups in terms of lung p53, p16, p21, and Bax mRNA levels.
Conclusions:
Our findings suggest that prenatal and adolescent CS exposure have a synergistic effect on lung function in mice. The combined effect did not appear to be a consequence of early pulmonary senescence.
Citation:En ligne : http://dx.doi.org/10.1289/EHP54 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9623 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Indoor environmental exposures and exacerbation of asthma : an update to the 2000 review by the institute of medicine Type de document : document électronique Auteurs : Watcharoot Kanchongkittiphon, Auteur Editeur : National Institute of Environmental Health Sciences Année de publication : 2015 Collection : Environmental health perspectives, ISSN 0091-6765 num. 123(1) Importance : p.6-20 Langues : Anglais (eng) Catégories : [PROMOSAN] allergie:cause d'allergie:facteur aggravant:pollution
[PROMOSAN] asthme
[TABAC] prévention:environnement sans fuméeIndex. décimale : AA 2.6.1. Habitation En ligne : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286274/ Format de la ressource électronique : HTML, PDF Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9400 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Metal concentrations in e-cigarette aerosol samples : a comparison by device type and flavor Type de document : document électronique Auteurs : Angela Aherrera, Auteur ; Joyce Jy Lin, Auteur ; Rui chen, Auteur Editeur : National Institute of Environmental Health Sciences Année de publication : 2023 Collection : Environmental health perspectives, ISSN 0091-6765 num. 131(12) Importance : p. 1-13 Présentation : graph.; tab. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:pod
[TABAC] chimie du tabac:constituant:additif:agent de saveur
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] étude
[TABAC] tabagisme:effet du tabac:altération des fonctions sensorielles:altération du goûtMots-clés : MOD Index. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : Background:
The rapid evolution of electronic cigarette (e-cigarette) products warrants surveillance of the differences in exposure across device types—modifiable devices (MODs), cartridge (“pod”)-containing devices (PODs), disposable PODs (d-PODs)—and flavors of the products available on the market.
Objective:
This study aimed to measure and compare metal aerosol concentrations by device type and common flavors.
Methods:
We collected aerosol from 104 MODs, 67 PODs (four brands: JUUL, Bo, Suorin, PHIX), and 23 d-PODs (three brands: ZPOD, Bidi, Stig) via droplet deposition in a series of conical pipette tips. Metals and metalloids [aluminum (Al), arsenic (As), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), lead (Pb), antimony (Sb), tin (Sn), and zinc (Zn)] were measured using inductively coupled plasma mass spectrometry (ICP-MS), results were log-transformed for statistical analysis, and concentrations are reported in aerosol units (mg/m3).
Results:
Of the 12 elements analyzed, concentrations were statistically significantly higher in MOD devices, except for Co and Ni, which were higher in PODs and d-PODs. Of the POD brands analyzed, PHIX had the highest median concentrations among four metals (Al, Ni, Pb, and Sn) compared to the rest of the POD brands. According to POD flavor, seven metals were three to seven orders of magnitude higher in tobacco-flavored aerosol compared to those in mint and mango flavors. Among the d-POD brands, concentrations of four metals (Al, Cu, Ni, and Pb) were higher in the ZPOD brand than in Bidi Stick and Stig devices. According to d-POD flavor, only Cr concentrations were found to be statistically significantly higher in mint than tobacco-flavored d-PODs.
Discussion:
We observed wide variability in aerosol metal concentrations within and between the different e-cigarette device types, brands, and flavors. Overall, MOD devices generated aerosols with higher metal concentrations than PODs and d-PODs, and tobacco-flavored aerosols contained the highest metal concentrations. Continued research is needed to evaluate additional factors (i.e., nicotine type) that contribute to metal exposure from new and emerging e-cigarette devices in order to inform policy.En ligne : https://doi.org/10.1289/EHP11921 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10578 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Trends in the exposure of nonsmokers in the U.S. population to secondhand smoke / James L. Pirkle (2006)
Titre : Trends in the exposure of nonsmokers in the U.S. population to secondhand smoke : 1988–2002 Type de document : texte imprimé Auteurs : James L. Pirkle, Auteur ; John T. Bernert, Auteur ; Samuel P. Caudill, Auteur ; Connie S. Sosnoff, Auteur Editeur : National Institute of Environmental Health Sciences Année de publication : 2006 Collection : Environmental health perspectives, ISSN 0091-6765 num. 114:6 Importance : p. 853-858 Présentation : tab., graph. Langues : Anglais (eng) Catégories : [DIVERS] géographie:Amérique:Amérique du Nord:Etats-Unis
[TABAC] chimie du tabac:fumée
[TABAC] étude
[TABAC] tabagisme:évaluation du tabagisme:marqueur
[TABAC] tabagisme:tabagisme passif:tabagisme environnementalIndex. décimale : TA 7.1 Généralités Résumé : The objective of this study was to describe the exposure of nonsmokers in the U.S. population to secondhand smoke (SHS) using serum cotinine concentrations measured over a period of 14 years, from October 1988 through December 2002. This study consists of a series of National Health and Nutrition Examination Surveys (NHANES) measuring serum cotinine as an index of SHS exposure of participants. Study participants were individuals representative of the U.S. civilian, noninstitutionalized population, ≥ 4 years of age. We analyzed serum cotinine and interview data from NHANES obtained during surveys conducted during four distinct time periods. Our results document a substantial decline of approximately 70% in serum cotinine concentrations in non-smokers during this period. This decrease was reflected in all groups within the population regardless of age, sex, or race/ethnicity. The large decrease that we observed in serum cotinine concentrations suggests a substantial reduction in the exposure of the U.S. population to SHS during the 1990s. The exposure of nonsmokers to SHS represents an important public health concern. Our findings suggest that recent public health efforts to reduce such exposures have had an important effect, although children and non-Hispanic black nonsmokers show relatively higher levels of serum cotinine. Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=8113 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TA 005669 TA 7.1 PIR T Article/Périodique Bibliothèque FARES Tabac Consultation sur place
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